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How does CBD work? Does it work for Dogs and Cats?


What is CBD and how does it work?

CBD (cannabidiol) is the non-intoxicating, non-psychoactive, chemical found in the cannabis plant. Currently, the only federally legal CBD, is CBD derived from hemp. Hemp is a plant that is the same species as the marijuana plant, but it is different in that it only contains 0.3 percent or less of THC! Hemp plants are also taller and skinnier than marijuana plants due to how each of them has been selectively bred over time for their different intended uses.


CBD is still being researched and there is still a lot to learn. But what we have learned so far is incredible! It is a pleiotropic drug, meaning that it produces many different effects through many different molecular pathways. Scientists have identified 65 different molecular targets of CBD! CBD is thought to interact with the endocrine system in our bodies, but it doesn’t seem to bind to the endocrine receptors (CB1 and CB2), but still interacts with them in other ways.


Crash Course in Biology!!

The first receptor CBD interacts with is the serotonin receptors, 5-HT1A. In high concentrations, CBD activates these receptors which produces an anti-anxiety affect by producing excitatory responses.


CBD also binds to TRPV1 receptors, which are ion channels known to mediate pain, inflammation, and body temperature. A fun fact is that capsaicin, the chemical in spicy peppers, also interacts with these receptors, but in the opposite way that causes pain.


Scientists also believe that CBD is able to work as an antagonist to block or deactivate the GPR55 receptors, or “orphan” receptors. (They are called orphan receptors because scientists still aren’t sure if they are a part of a bigger family or receptors) They are in the cerebellum and promote osteoclast cell function which facilitates bone reabsorption. Overactive GPR55 receptors are associated with osteoporosis and also promote cancer cell proliferation. Since CBD blocks these receptors, it may act to decrease both bone reabsorption and cancer cell proliferation according to Ruth Ross of the University of Aberdeen.


Blocking the GPR55 receptors aren’t the only potential anti-cancer affects of CBD. It also activates PPARs, which are receptors on cell nuclei. And when these receptors are activated, they have anti-proliferative effects, the ability to induce tumor regression in human lungs, and degrades amyloid-beta plaque which is what has been linked to Alzheimer’s disease. And if that isn’t enough, the PPAR’s also regulate genes that are involved in lipid uptake and insulin sensitivity which means that diabetics may benefit from CBD too!


And lastly, if you have made it this far, you probably could go crush a Biology 101 test now! But, before you do that, here is the last CBD impact we will be discussing. Along with all of the other amazing impacts of CBD, it has been shown to function as an allosteric receptor modulator. This means it can either enhance or inhibit the signals certain receptors transmit by changing the shape of those receptors instead of binding to them. Australian scientists have found that CBD is able to change the shape of GABA-A receptors to enhance it’s binding affinity for GABA, the main inhibitory neurotransmitter in mammal’s central nervous systems. GABA has a natural calming affect and since CBD makes the GABA-A receptors bind even more to the GABA in our systems, the amplification of the calming affect helps to reduce anxiety.


So, to summarize all of these awesome impacts of CBD. CBD helps the body calm down and counteract anxiety, mediates pain and inflammation and body temperature, fight against cancer cell growth and even reduce tumors, and finally fights against amyloid-beta plaque. What an absolutely incredible chemical!


Are Dogs and Cats just like Humans when it comes to CBD?

Here is the good news! Dogs and cats both have all of the above receptors and the same endocrine system as us humans! So, all of the awesome results of the CBD above should also be true for our furbuds! There still needs to be a lot of research done on how CBD impacts dogs and cats, but what we know so far points to real benefits for them! And as we keep using CBD and grow the popularity of it, we will be able to continue doing amazing research on it!


Now with that said, not all CBD products are created equal, and there are a lot of scammers in the industry. So make sure you stick with a company and product you can trust and love! We at Furbud Foods, pride ourselves in our high-quality dog and cat CBD supplement, Wagnificent CBD. We put the CBD into a flavorful powder form, beef and tuna, that also includes probiotics which are essential for your furbud’s gut health, mental health, and immune system! The beautiful part is that you can buy Wagnificent and get more CBD plus probiotics for a better price than you get plain old CBD oil and treats from other companies! Check out our selection here and order today because its never too early to start giving your best friends all of the amazing benefits above!




Where we got our information – Credit where credit is due:

https://www.projectcbd.org/science/how-cbd-works

https://www.analyticalcannabis.com/articles/hemp-vs-marijuana-is-there-a-difference-311880

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200052/

https://veterinaryrecord.bmj.com/content/160/9/311.4

https://pubmed.ncbi.nlm.nih.gov/29882158/

https://pubmed.ncbi.nlm.nih.gov/32095931/


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